The idea that the effects of aging can be reversed is continually be researched. Finding the fountain of youth is something many people wish for, and now that wish could be materializing. There is new evidence of proteins that could be critical to fight for anti-aging.

This article in offers more details:

Newly Discovered Proteins Key to Future Anti-Aging Drugs | Anti-Aging News

Aging coincides with a loss of muscle mass which saps energy and is noticeable by middle age, becoming more pronounced heading into retirement. However, there is more hope today, as scientists from the University of Nottingham have discovered new proteins that could hold far-reaching implications in the science of Gerontology. The research published in the journal Aging could lead to new class of drugs designed to combat the debilitating effects of age-related diseases like Alzheimer’s and Parkinson’s Disease, and even aging itself.

Target the Proteins to Slow Down the Aging Process

The research centered on a class of proteins (carbonic anhydrase) that are located in the cells mitochondria, which processes oxygen we breath and then converts it to energy. Lead researcher Doctor Lisa Chakrabarti is excited about the progress being made, saying they think they understand the role the protein plays in the cell’s aging process. The goal now is to find the best way to target the protein inside the mitochondria to slow down the aging process in the human body, while limiting any harmful side effects.

She says this research could open new possibilities in targeting many degenerative diseases, as well as other aging effects in the body.The scientists used a special process to separate the proteins from within the mitochondria of muscle and brain cells from young and middle-aged people. After comparing samples from the both groups, they discovered that these proteins were in greater quantities in brain samples from:

  • middle aged people who were aging normally
  • younger people suffering from age-related symptoms

Read the full post here:  Newly Discovered Proteins Key to Future Anti-Aging Drugs | Anti-Aging News

In this video, a similar idea is discussed concerning cells and how they age. In this case, the senescent cells are eliminated with a protein drug. This method has been shown to increase the lifespan of test mice:

Just as the two above posts are proclaiming new advances in anti-aging drugs through targeting proteins in the cells, the following article somewhat disavows the findings that slowing down the aging process through carbonic anhydrase proteins, saying the research may not have been as thorough as first thought:

Researchers Tout Protein That May Help Slow Aging Process

Just because a protein is more common in aged brains doesn’t mean the protein is a cause of aging, degeneration, or anything else. Bodies are complicated and for all the researchers know, the protein is caused by brain degeneration or aging, or is connected to some unrelated third factor.

The nematodes in question (c. elegans) have an average lifespan of about two weeks. Any change in this is going to appear to have larger statistical impact because even a one-day alteration in life span can appear impressive when you only have roughly 14 to start with. While nematodes are used in aging research to good effect, saying that an unknown amount of a protein made your worms die early—without even mentioning how or why—tends to raise more questions than answers.

Aging hand

Wikimedia Commons

The function of carbonic anhydrase in the body has to do with regulating pH balance. No explanation is given of how or why this connects to aging or degeneration in the brain. If you are going to start researching ways to target a protein in the hope of limiting the aging process, it helps to be able to articulate how that protein impacts aging in the first place.

Read the full post here:  Researchers Tout Protein That May Help Slow Aging Process

Even if the outcome of the research doesn’t lengthen our lifespan in the near future, there is no doubt that it will happen. A lot of time and money has been spent exploring a way to help humans living longer, healthier lives. Having the outside shell of our bodies cosmetically altered is one thing, but figuring out a way to help fight disease and reverse the aging process is fundamental.